Paul, I don't recommend I-44, it is as rough an interstate as I-10 is in Louisiana. You could take I70 across and then drop down to Springfield or as Kevin said take US 60 Mike and Marianne Keith WBCCI 4503, Grater St Louis 3rd VP New Florence, MO 75 Argosy 26' center twin rear bath 96 Ford F-250 Powerstroke